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Single Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy (SADI-S)

A powerful metabolic operation combining a sleeve with a pylorus-preserving intestinal bypass.

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Understanding your options

Choosing a bariatric procedure is a personal decision. This guide explains what the operation involves and the factors your surgical team may consider.

Personalized selection matters. These descriptions are educational, not a diagnosis or a guarantee of eligibility. Your surgeon will review your medical history, symptoms, investigations and treatment goals.

How the procedure works

SADI-S combines a sleeve gastrectomy with division of the duodenum just beyond the pylorus. The proximal duodenum is joined to the distal ileum in one duodenoileal anastomosis, creating a shorter common channel for food and digestive secretions. The pylorus is preserved.

Who is this procedure best suited for?

SADI-S may be particularly relevant for selected patients with BMI 50 or higher, significant type 2 diabetes, or a need for greater weight loss or metabolic effect. It may also be an option after a prior sleeve when further weight loss is needed. BMI and diabetes alone do not determine the best operation, and significant reflux may favour RYGB.

Potential benefits

SADI-S can deliver substantial weight loss and improvements in metabolic conditions. Its single intestinal anastomosis and preserved pylorus are distinctive features.

Risks and important considerations

The procedure has important nutritional risks, including protein-calorie malnutrition and fat-soluble vitamin and mineral deficiencies. Diarrhea, altered bowel habits, bile reflux, leak and other surgical complications are possible. Lifelong supplementation and monitoring are especially important.

Recovery and follow-up

Recovery requires staged nutrition, careful protein intake, individualized supplementation and regular lifelong laboratory monitoring. Patients must be willing and able to attend long-term follow-up.

What does the evidence show?

SADI-S is a recognized metabolic/bariatric procedure with strong weight-loss potential, but the optimal choice depends on patient characteristics and the balance between metabolic benefit and nutritional burden.

Further reading

ASMBS: SADI-S

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Information is summarized in original patient-friendly language. No anatomical diagrams are reproduced here pending licensing and review.

Ready to discuss your options?

The right procedure depends on much more than BMI alone. A consultation can help clarify which treatment fits your needs and priorities.

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